TBI Study

The ADVANCE TBI study investigates the effects of traumatic brain injury (TBI) on brain health in ADVANCE participants.

The TBI study is led by Professor David Sharp from Imperial College London, and his team are using state-of-the-art techniques to look at long-term brain health as part of the core ADVANCE investigations. One of the aims of the study is to inform disease prevention in the future, in both military and civilian settings, as well as assist in the early diagnosis of neurodegenerative disease.

With this study we also aim to develop a better understanding of:

  • How common traumatic brain damage is within the ADVANCE cohort, and how it relates to the number and type of head injuries.
  • Whether participants with TBI develop neurological or psychological problems over time.
  • Whether early changes of dementia are detectable in the participants with evidence of previous TBI (using advanced brain scanning and blood test analysis).

Having a better understanding of all these factors will help us develop new preventative treatments in high risk groups. Eligible ADVANCE participants are offered the chance to take part in the TBI study as part of their usual follow-up visits. The assessments will include MRI scans of the brain as well as computerised cognitive assessments, and all tests will be done at Stanford Hall.