Published key findings from the ADVANCE baseline data are summarised below. Full publications and summaries of the key publications can be found further down the page.

Summary of the key findings from the ADVANCE baseline data to date:

• Cardiovascular risk was found to be slightly increased in the injured cohort compared to the uninjured cohort, but the differences are not big enough to warrant any medical treatment at this stage.
• The injured non-amputees were found to have greater rates of depression, anxiety and post-traumatic stress disorder (PTSD) compared to those with amputations and the uninjured participants. Participants with amputations and the uninjured participants reported similar rates of mental health issues.
• The participants with amputations reported greater rates of post-traumatic growth (PTG) compared to the injured non-amputees and the uninjured group. Pain was associated with a higher likelihood of reporting PTG.
• Lower bone mineral density was seen in the hip of the amputated side of participants with amputation injuries compared to the rest of the cohort. No other significant differences in bone health were seen within the cohort.
• Heart rate variability (HRV) was found to be lower in the injured group compared to the uninjured group.