Hypothesis
For OA: 1. The injured group will have accelerated OA compared to the uninjured group 2. The amputee group will have accelerated OA on the contralateral knee 3. The knee injury group will have accelerated OA
For BMD: 1. BMD in the uninjured group will decline at normal rates with age. 2. BMD in the injured group will be lower than the uninjured group (the difference will be the same as in baseline data) (this change will be due to the inclusion of the amputees) 3. BMD will remain the same in osseointegrated amputees (& be similar levels to uninjured) 4. BMD will remain the same in amputees (& be lower than uninjured) UPDATE The observed differences in DASH score will be due to differences in pain and medication, e.g. participants with multiple amputations will take more pain medication and therefore score better on DASH.
Summary
The project aims to compare OA and BMD results between baseline and FU1 in a preliminary subset of the data. The aims also include a review of pain and medication to check if it explains the differences seen in DASH scores between amputee groups.
The hypotheses of the project are:
For OA:
1. The injured group will have accelerated OA compared to the uninjured group.
2. The amputee group will have accelerated OA on the contralateral knee.
3. The knee injury group will have accelerated OA.
For BMD:
1. BMD in the uninjured group will decline at normal rates with age.
2. BMD in the injured group will be lower than the uninjured group (the difference will be the same as in baseline data) (this change will be due to the inclusion of the amputees)
3. BMD will remain the same in osseointegrated amputees (& be similar levels to uninjured)
4. BMD will remain the same in amputees (& be lower than uninjured)
5. The observed differences in DASH score will be due to differences in pain and medication, e.g. participants with multiple amputations will take more pain medication and therefore score better on DASH.
Keywords
Osteoarthritis, Bone Mineral Density, Amputation